The practical implications for clinical radiotherapy are important. A much larger proportion of damage would therefore remain unrepaired at several half-times than is estimated by current mono- or biexponential models. Straight reciprocal plots mean that in a constant time interval tau the unrepaired damage falls from 1 to (1/2), then from (1/2) to (1/3), then (1/3) to (1/4), etc. These reciprocal plots describe well with one parameter tau, the first half-time, repair curves previously thought to be "biexponential", and to require three parameters. However, plotting the CD3 channel against FSC-A with the flowJo software. Different animal data showed no inconsistency with straight reciprocal plots. In Figure 2a, the flow rate takes about 10 s to stabilize but usually strong. By default, FACSDiVa uses a width basis of -100, whereas FlowJo's default is -10. The number of channels around zero that are transformed into the linear realm is defined by the width basis. If the reciprocal model applies, the graphs would be straight lines. Near zero, the log scale becomes linear so that zero can be defined, and then goes back to log when safely in the negative realm.
![biexponential plots flowjo 10 biexponential plots flowjo 10](https://image.slidesharecdn.com/d1007arduinoosdpt2014geotechexamples-140910165422-phpapp01/95/geotechnical-examples-using-opensees-50-638.jpg)
Graphs are presented of the reciprocal proportion of damage remaining as a function of the interval between the two doses. Published repair data were reanalyzed from laboratory animal experiments that employed split doses or two fractions per day. The present paper investigates whether such plots of hyperbolic or reciprocal repair are relevant for laboratory animal tissue results. Two processes have been suggested as causing this: (1) a second-order process (bimolecular) instead of first-order (exponential) and (2) a skewed distribution of monoexponential rates.
![biexponential plots flowjo 10 biexponential plots flowjo 10](https://media.springernature.com/lw685/springer-static/esm/art:10.1038%2Fs41556-019-0445-8/MediaObjects/41556_2019_445_Fig11_ESM.jpg)
For repair of DNA strand breaks, plotting the reciprocal of proportion unrepaired as a function of time yielded straight lines.
![biexponential plots flowjo 10 biexponential plots flowjo 10](https://i.ytimg.com/vi/CBkM2FnqmXo/maxresdefault.jpg)
Increasing numbers of animal experiments in situ are reporting that repair of sublethal radiation damage in vivo slows down with time, usually described as two components of (monoexponential) repair.